25 More research is needed to better understand the impact of using kratom rein combination with other substances. (See Is kratom safe?)

NIDA is a biomedical research organization and does not provide personalized medical advice, treatment, counseling, or legal consultation. Information provided by NIDA is not a substitute for professional medical care or legal consultation.

The 7-hydroxymitragynine may have a higher affinity for the opioid receptors. Partial agonist activity may be involved.

Kratom is being studied in order to design novel drugs for treating pain, opioid use disorder, and alcohol use disorder.

Respiratory depression is the leading cause of death from opioid use.[59] Although evidence is sparse, the risk of respiratory depression caused by taking kratom appears to be low, but as of 2016[update] the Food and Drug Administration listed respiratory depression as a concern.

As of 2013[update], kratom was listed by ASEAN hinein its Beilage of products that cannot be included hinein traditional medicines and health supplements that are traded across ASEAN nations.[78]

 (DSM-5)—a reference Liedertext published by the American Psychiatric Association that health professionals use to diagnose substance use disorders and other psychiatric disorders—does not include a specific diagnosis related to kratom use.

Kruegel AC, Grundmann O (2018). "The medicinal chemistry and neuropharmacology of kratom: A preliminary discussion of a promising medicinal plant and analysis of its potential for abuse".

Kratom overdose is a subject of concern rein many countries because of the associated rising number of hospitalizations and deaths hinein which chronic kratom use is a contributing factor.[12][17] According to clinical reviews, a kratom overdose can cause liver toxicity, seizures, coma, and death,[17] especially hinein combination with excessive alcohol use.

“Kratom” commonly refers to an herbal substance that can produce opioid- and stimulant-like effects. Kratom and kratom-based products are currently legal and accessible rein many areas, though U.S. and international agencies continue to review emerging evidence to inform kratom policy.1

Phytoextractum is proud to offer you a wide variety of superior quality Kratom powders, extracts, capsules, and more. Sourced from the leaves of the Mitragyna speciosa tree, Kratom is by far one of our most popular products.

hinein addition to alkaloids, M. speciosa here produces many other secondary metabolites. These include various saponins, iridoids and other monoterpenoids, triterpenoids such as ursolic Lsd and oleanic Lysergic acid diethylamide, as well as various polyphenols including the flavonoids apigenin and quercetin.

The plant's active compounds and metabolites are not detected by a typical drug screening test, but can Beryllium detected by more specialized testing.

Mitragynine is classified as a kappa-opioid receptor agonist and is roughly 13 times more potent than morphine. Mitragynine is thought to be responsible for the opioid-like effects.